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BioTechCircle News®

October 2011

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Issue 100

See all previous issues at our archives; follow us on Twitter.

For a sneak preview of site updates and analysis of the latest research reports,
(Articles and gene-related Patents, Patent Applications), subscribe to our
newsletter at the bottom of our home page.

In this Articles section: links to 86 free Web articles in 15 major categories.
Click on the category list below to go immediately to that section.

Starting with the last issue, we are combining the categories "Research Advancements"
and "Therapeutic Category." Each uses the same medical condition subcategories.
We originally separated them to differentiate between experimental and applied
treatments; however, since most of you are interested in the medical conditions, not
the development status of the treatment, we trust this streamlining will be easier for
you to find what you need.

The major categories below are further subdivided to make it easy for you to locate
news and technology developments, the business and the markets in the life sciences
of particular interest to you. The brief synopses will help you decide which articles you'd
like to read. Simply click on the article's title to go directly to the original article.

Here are this month's major categories:

Agri-Biotech (7 articles)
Biobusiness Management (5 articles)
BTC's News You Can Use (5 articles)
Industry (10 articles)
Clinical Trials (1 article)
Diagnostic Tools (6 articles)
Drug Delivery (1 article)
Investments/Government Support (3 articles)
Novel Applications (4 articles)
Patents (1 articles)
People Profiles (2 articles)
Personalized Medicine (1 article)
Platform Technologies (14 articles)
Research Advancements (19 articles)
Research Tools (7 articles)

For a brief explanation of how we categorize the articles, please see "Express Guide
to Monthly Web Articles
."

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	AGRI-BIOTECH

Subcategory: Animal

Cattle Parasite Vaccine Offers Hope to World’s Poorest Farmers
Keith Matthews BBSRC (28-Oct-11)
Technique uses a harmless parasite to carry medicines into cows'
bloodstream.The treatment could offer long-term protection against common
conditions such as foot-and-mouth disease or bovine tuberculosis, as well as a
range of other diseases.

Subcategory: Crops

Smarter Toxins Help Crops Fight Resistant Pests
Daniel Stolte University of Arizona (09-Oct-11)
A slight change in molecular structure introduced by genetic engineering gives
crop-protecting proteins called Bt toxins a new edge in overcoming resistance
of certain pests such as the diamondback moth, one of the world's most
destructive.

Plants Feel the Force
Diana Lutz Washington University in St. Louis (21-Oct-11)
Plant movements, both fast and slow, are ultimately all hydraulically
powered; scientist thinks the mechanism is related to mechanosensitive ion
channels that cause bacteria to swell. May lead to understanding stunted
growth in plants.

Subcategory: Environment

Future Forests may Soak up More Carbon Dioxide than Previously Believed,
Helping to Buffer Climate Change

Jim Erickson University of Michigan (13-Oct-11)
A 12-year study at a 38-acre experimental forest, bathed in elevated levels of
carbon dioxide and ground-level ozone, continued to grow at an accelerated
rate throughout the 12-year experiment.

Plant Genomes May Help Next Generation Respond to Climate Change
Richard Lewis Brown University (06-Oct-11)
Climate is the agent that determines the suite of genes that gives the plant the
best chance of surviving and reproducing throughout its natural range. The
finding may unlock the molecular basis for other plants’ adaptability to
climate change.

Subcategory: Food

With Mice, Urine Powers Social Networking
Sarah Everts Chemical & Engineering News (03-Oct-11)
Information gained from urine influences one mouse’s response to another.
Researchers may be able to leave these rodents chemical messages that deter
them from eating valuable provisions, particularly in developing nations where
food is scarce.

Subcategory: Microorganisms

Suggested Explanation for Glowing Seas--Including Currently Glowing
California Seas

National Science Foundation (18-Oct-11)
Discusses potential mechanism for marine bioluminescence (blue flashes seen
at night and red tide) caused by tiny, unicellular plankton known as
dinoflagellates.

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	BIOBUSINESS MANAGEMENT

Subcategory: Animal

Advertising Goes to the Dogs
Neil Schoenherr Washington University in St. Louis (13-Oct-11)
Dog food commercial contains squeaks similar to a dog toy, a whistle barely
heard by humans and a high-pitched pinging noise. Experts say this should
serve to increase the bond owners feel with their pets.

Subcategory: Education

Manage First to Put Safety First
Nathan Watson R & D Magazine (18-Oct-11)
Automation can help increase training compliance and laboratory safety
without relying on researchers or increasing laboratory safety staff and
budget. Outlines strategies that can help an organizaton develop an effective,
automated training system.

Subcategory: Mobile, phones/others

How the Health-Care System Slows Mobile Medical Technology
Emily Singer Technology Review (04-Oct-11)
Fee-for-service structure inhibits technology adoption. "It doesn't matter how
good these technologies are; if doctors can't get reimbursed for looking at
blood-pressure data that the patient records at home, they are not going to do
it."

Subcategory: Privacy/ Records Management

You’re not so Anonymous
Caroline Perry Harvard University Gazette (18-Oct-11)
Prescription information is routinely sold to companies for use in research and
pharmaceutical marketing. Under federal privacy law, this data sharing is
perfectly legal. Advocates system allowing productive data sharing while
guaranteeing privacy.

Subcategory: Regulatory/ Government

Eric Perakslis Appointed New CIO of FDA
Bio-IT World (10-Oct-11)
“The commissioner has given me license to bring positive change to the
agency and I am looking to engage our scientific/technologic community
openly to make good things happen,” Eric Perakslis says.

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	BTC'S NEWS YOU CAN USE

Subcategory: Food

Green Vegetables Directly Influence Immune Defences and Help Maintain
Intestinal Health

BBSRC (14-Oct-11)
Leafy green vegetables have been shown to influence our intestinal health by
delivering a protective factor to certain cells of the immune system. May help
understand the basis of intestinal inflammatory disorders such as
inflammatory bowel disease.

British Scientists Grow Super Broccoli
Maria Cheng Manufacturing.net (26-Oct-11)
New broccoli contains 2-3 times the normal amount of glucoraphanin, a
nutrient believed to help ward off heart disease. part of an increasing tendency
among producers to inject extra nutrients into foods. "Vegetables are a
medicine cabinet," say experts.

Is It Important to Include Probiotics and Prebiotics in a Healthy Diet?
Katherine Zeratsky, R.D., L.D. Mayo Clinic (15-Sep-11)
Probiotics are microorganisms that may help with digestion and offer
protection from harmful bacteria. Prebiotics are nondigestible carbohydrates
found in whole grains, bananas and other foods that act as food for probiotics.

How Probiotic Yogurt Works
Bob Grant The Scientist (26-Oct-11)
Researchers show that the bacterial species in probiotic, fermented dairy
products may alter gene expression and metabolism in native gut microbiota.

Subcategory: Misc. Medical Devices

Technologies for Healthier Living
Emily Singer Technology Review (01-Oct-11)
Click on each of the photos below the colorful posture sensor for the 5
remaining featured apps, devices and platforms from the Health 2.0
Conference.

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	CLINICAL TRIALS

Subcategory: Collaboration

Oracle Health Care Cloud Application Captures Data on Therapy Outcomes
Brian T. Horowitz eWeek (17-Oct-11)
OutcomeLogix On Demand 3.0 is a Web-based application that enables life
science companies and contract research organizations to collect data on the
outcome of various therapy treatments in late-stage trials.

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	DIAGNOSTIC TOOLS

Subcategory: Environment

This Will Take Your breath Away
Michael Berger Nanowerk (24-Oct-11)
Sampling and analysis of gaseous components in human breath offers a
noninvasive and quick means of qualitatively and quantitatively assessing
internalized doses of environmental contaminants. Need is for portable,
easy-to-use screening systems.

One Room – 63 Different Dust Particles? Researchers Aim to Build Dust Library
Pam Frost Gorder Ohio State University (05-Oct-11)
New patented sensor shows that most dust is natural in origin; organic matter
is most common, followed by quartz. Dust composition is important than in
public health, where some airborne particulates have been linked to diseases.

Subcategory: Mobile, phones/others

Smart-Phone App Tracks Heart Rate
Erica Westly Technology Review (14-Oct-11)
A new smart-phone app can take your pulse and measure your breathing. All
you need to do is hold an index finger over a smart phone's video camera for a
few minutes. Readings were almost identical to electrocardiographs, pulse
oximeters.

Subcategory: Neurology

Into the (Mis)fold: a Diagnostic Tool for Proteins
Aditi Risbud Berkeley News (31-May-11)
Alzheimer’s disease affects more than 35 million people worldwide. A central
aspect to this disease is an accumulation of misfolded proteins in the brain.
New capability could help pinpoint Alzheimer’s in its early stages, enable
new therapies.

Subcategory: Oncology

Difference Engine: Blissful Ignorance
Economist (14-Oct-11)
The real problem with prostate-cancer screening—whatever the test
employed—is the over-treatment that ensues. What is needed is a way of
identifying the fast-growing version of the disease while ignoring all the other
cells.

Singling Out the Real Breast Cancer among the Lumps
Mary Beckman Pacific Northwest National Laboratory (24-Oct-11)
Using patient blood, a panel of proteins shed by breast cancer are found to be
easily detected by standard diagnostic tools and can distinguish between real
cancer and benign lumps.

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	DRUG DELIVERY

Subcategory: Cell Therapy

Researchers Do Precise Gene Therapy without a Needle
Pam Frost Gorder Ohio State University (16-Oct-11)
Electricity “shoots” bits of therapeutic biomolecules through a tiny channel
and into a cell in a fraction of a second. This “nanochannel electroporation,” or
NEP, helps investigate how drugs, other biomolecules affect cell biology and
genetic pathways.

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	INDUSTRY

Subcategory: Big Pharma

Huge Improvement in Reputation of the Auto Industry and Big Drop in
Reputation of Airlines

Harris Polls (21-Sep-11)
Table shows results of how the public perceives major industries, including
pharmaceutical, managed care and health insurance companies. All 3 showed
major drops in reputations over a 14-year period.

Subcategory: Education

HHMI Debuts “The Making of the Fittest” Short Films
Howard Hughes Medical Institute (12-Oct-11)
Three short science films use vivid storytelling to teach the vital concepts of
adaptation and natural selection. Created to be used in classrooms, films try to
put kids in the footsteps of past or present scientists leading to a scientific
discovery.

Subcategory: Energy/ Fuel

EIA Projects World Energy Use to Increase 53 Percent by 2035; China and India
Account for Half of the Total Growth

U.S. Energy Information (19-Sep-11)
Presents key findings of International Energy Outlook 2011 (IEO2011).
Report presents updated projections for world energy markets through 2035.
Link to full report.

Subcategory: Environment

Argonne Team Helps Map Fukushima Radiation Release
Louise Lerner Argonne National Laboratory (10-Oct-11)
Describes the challenges of taking radiation samples in a mountainous,
forested area damaged by earthquake. Data sharing, training of U.S. military
and Japanese personnel in Japan has been coordinated and ongoing.

What Can Make a Dent?
David L. Chandler MIT News (24-Oct-11)
Given the enormous scale of worldwide energy use, there are limited options
for achieving significant reductions in greenhouse gas emissions. First of
5-part series taking a broad view of the likely scalable energy candidates.

Biodiversity
Thomas E. Lovejoy and Edward O. Wilson
The Scientist (01-Oct-11)
Ecosystems are failing and extinction rates are soaring. Experts explore why
cataloging existing species, discovering new ones, and maintaining a balanced
and diverse global ecosystem are critical for ensuring a habitable environment
for all.

Subcategory: Geographic focus

Industrial Biotech Jobs Soar, Sector Asks for Policy Help
Ron Leuty San Francisco Business Times (05-Oct-11)
California biofuels companies and others in the "industrial biotechnology"
sector increased employment by 632% over the past 5 years, albeit from a
low starting base.

Subcategory: Miscellaneous

Insect Portrait Captures Small World Competition
Drug Discovery & Development (05-Oct-11)
A micrograph of a Common Green Lacewing earned top honors in Nikon’s
2011 Small World Photomicrography Competition. The competition
recognizes excellence in photomicrography.

Top 50 Technologies Reshaping the World
Rajiv Kumar Frost & Sullivan (01-Oct-11)
Selected 50 technologies are divided across 9 technology clusters, among them
Lifesciences & Biotechnology (5), Medical Devices & Imaging Technology
(6), Clean & Green Technology (7).

Subcategory: Nanotechnology

Nanoparticles and Their Size may not Be Big Iissues
University of Oregon (24-Oct-11)
Nanoparticles have been in contact with humans for a long, long time, as
miniscule metal nanoparticles are being created naturally by silver articles such
as wire, jewelry and eating utensils in contact with other surfaces.

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	INVESTMENTS/ GOV. SUPPORT

Subcategory: Databases

Healthy Competition
Economist (10-Apr-11)
Heritage Health Prize: $3m award will go to whoever does the best
job of improving predictions about which patients in a model set are most
likely to require a visit to hospital within the next year.

Subcategory: General

BBSRC Encourages Applications in Industrial Biotechnology and Bioenergy
BBSRC (05-Oct-11)
Researchers working in industrial biotechnology and bioenergy as well as in
related fields including systems biology, microbiology, biochemical
engineering, and chemistry are encouraged to submit proposals. Deadline Jan.
11 2012.

Subcategory: Pulmonary/ Respiratory Diseases

Feature: Breathless - Understanding Asthma
Penny Bailey Wellcome Trust (20-Sep-11)
Six different asthma subsets or 'phenotypes' identified, based on when the
disease first appeared and its remission or persistence over a life time.

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	NOVEL APPLICATIONS

Subcategory: Energy/ Fuel

Converting Plastics to Energy Could Boost US Reserves
Ann R. Thryft Design News (26-Oct-11)
Plastics make up only 9.5-17% of each state's municipal solid wastes, yet
many plastics are more energy dense than coal. Nonrecycled plastics can be
source-separated and converted to crude oil or other types of fuel oil via
pyrolysis.

VIDEO: Unlocking New Energy Possibilities with Dead Wood
IMPO (27-Oct-11)
Could dead wood be the answer to the world's energy problems? Scientists
have invented a simple 2-step way to turn wood, and even garbage, into fuel
that could power your car and heat your home. Video.

Artificial Leaf’ Makes Fuel from Sunlight
David L. Chandler MIT News (30-Sep-11)
Like living leaves, artificial leaf (a silicon solar cell with different catalytic
materials bonded onto its two sides) can turn the energy of sunlight directly
into a chemical fuel that can be stored and used later as an energy source.

Subcategory: Environment

Extraordinary Off-Grid Hobbit Home in Wales Only Cost £3,000 to Build
Tafline Laylin Inhabitat (05-Oct-11)
Describes a home that has virtually no visual or environmental impact on the
surrounding landscape. The naturally lit family home uses locally-sourced and
natural materials taken from nearby woodlands.

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	PATENTS

Subcategory: Cell Therapy

EU Court: No Patents for Some Atem Cell Techniques
Maria Cheng The Salt Lake Trib (18-Oct-11)
The European Union’s top court ruled that scientists cannot patent stem cell
techniques that use human embryos for research. responding to Greenpeace
lawsuit. Concerned that patents on plants and animals could lead to
monopolies in food production.

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	PEOPLE PROFILES

Subcategory: Computing Systems

Americans Recall Personal Impacts of Jobs' Vision
Brooke Donald Physorg.com (07-Oct-11)
Comments include a parent telling how an app allows severely disabled son to
communicate through iPad and iPhone; medical and patient entertainment
uses in hospitals; cotton and soybean farmer to check pesticide and
temperature monitoring.

Subcategory: Miscellaneous

PopSci's 10th Annual Brilliant 10
PopSci (08-Sep-11)
Magazine's yearly list of young geniuses shaking up science includes
scientists making new forms of geometry, better HIV drugs, studying sun
plasma and sludge ecosystems, butterfly pharmacology and more.

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PERSONALIZED MEDICINE

Subcategory: Nanotechnology

Opinion: Miniaturizing Medicine
Chad Mirkin The Scientist (01-Oct-11)
Methods help track disease markers early, monitor disease progression; brings
us closer to the implementation of personalized medicine. May lower
health-care, drug development costs. See
http://the-scientist.com/2011/10/01/opinion-miniaturizing-medicine/
 

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	PLATFORM TECHNOLOGIES

Subcategory: Cell Therapy

Scripps Research Scientists Find Stem Cell Reprogramming Technique Is Safer
than Previously Thought

Scripps Research Institute (06-Oct-11)
Study shows that the standard reprogramming method can generate induced
pluripotent stem cells with very few DNA structural mutations, which are
often linked to dangerous cell changes such as tumorigenesis.

Subcategory: Earth Science

From Myth to Reality: Photos Prove Triple Rainbows Exist
The Optical Society (05-Oct-11)
Although staggeringly rare, tertiary and quaternary rainbows are natural
products of the combination of refraction, dispersion, and reflection inside
raindrops. These are the same processes that create all rainbows. Photos.

Subcategory: Environment

A New Approach to Solar Power
David L. Chandler MIT News (21-Oct-11)
A thermoelectric system embedded in the central tube of a parabolic-trough
system produces both hot water and electricity at the same time by using a
thermosiphon that draws heat away from the “cold” part of a thermoelectric
system.

Subcategory: Food

Call In The Food Fixers
Melody M. Bomgardner Chemical & Engineering News (30-Oct-11)
Whenever fats, sugars, or gluten are taken out of foods for "light" or "-free"
versions, a precisely tailored combination of other ingredients is called upon
to replace them to build up viscosity and "mouth feel."

Subcategory: Genomics

How Zelda Kick-Starts the Fly Embryo’s Genome
Howard Hughes Medical Institute (20-Oct-11)
A new class of protein, nicknamed Zelda, is discovered to work as a genomic
"on" switch for the molecular events that govern the handoff from mother's
influence to an animal's own genome, the maternal-to-zygotic transition
(MZT).

Opinion: Thinking Outside the Genome
Stephen Friend The Scientist (01-Oct-11)
Early sequencing evolved into the publication of genomes for myriad species,
including our own, within the span of 25 years. By extending its reach beyond
science, the field of omics will change the way we live our lives, writes
Friend.

Subcategory: Health Gaming

Video Games Help ICU Patients With Physical Therapy, Study Finds
iHealthBeat (11-Oct-11)
Interactive video games on consoles such as the Nintendo Wii and Wii Fit are
found to enhance physical therapy for patients in intensive care units. Study
evaluated 22 patients ages 32-64.

Subcategory: Materials

Making Sodium-ion Batteries that Are Worth Their Salt
Jared Sagoff Argonne National Laboratory (24-Oct-11)
Sodium-ion technology possesses a number of benefits that lithium-based
energy storage cannot capture. More naturally abundant than lithium, sodium
is lower in cost and less susceptible to extreme price fluctuations as the
battery market rapidly expands.

Research Finds Gallium Nitride is Non-Toxic, Biocompatible – Holds Promise
For Biomedical Implants

North Carolina State (24-Oct-11)
The semiconductor material gallium nitride (GaN) holds promise for an array
of implantable technologies – from electrodes used in neurostimulation
therapies for Alzheimer’s to transistors used to monitor blood chemistry.

Stanford Researchers Build Transparent, Super-stretchy Skin-like Sensor
Louis Bergeron Stanford University (24-Oct-11)
Sensor can be stretched to more than 2x its original length, bounce back
perfectly to its original shape, can sense pressure from a firm pinch to
thousands of pounds. Applications include prosthetic limbs, robotics,
touch-sensitive computer displays.

Scientists and Engineers Create the ‘Perfect Plastic
University of Leeds (29-Sep-11)
Breakthrough will allow experts to create the 'perfect plastic' with specific
uses and properties by using a high-tech 'recipe book' based on mathematical
models. It will also increase ability to recycle plastics.

Subcategory: Microorganisms

'Demilitarized Zone' Keeps Gut Bacteria Where They Belong
Howard Hughes Medical Institute (13-Oct-11)
Trillians of bacteria in our guts are physically separated from the intestinal
lining, which prevents them from activating their host's immune system. Loss
of this protective barrier could be involved in inflammatory bowel, related
diseases.

Subcategory: Miscellaneous

Genetic Alarm Clock
Jef Akst The Scientist (04-Oct-11)
Researchers have pinpointed a gene that helps initiate the morning metabolism
ramp up—a discovery that could provide clues for disorders such as
insomnia, aging, even cancer and diabetes.

Subcategory: Robotics

All for one, 'R-one' for all
Rice University (11-Oct-11)
"Swarm" robots work collectively on tasks -- like a colony of ants or bees --
and can do some jobs faster and better than humans. Applications include oil
spills and searching for earthquake survivors. Cost is about $200.

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	RESEARCH ADVANCEMENTS

Subcategory: Cardiology/ Vascular Diseases

Fatty Acids Do A Heart Good
Lauren Wolf Chemical & Engineering News (31-Oct-11)
The identification of fatty acid molecules, which trigger pythons’ heart cells
to expand as much as 40% so that the snakes can metabolize big meals, could
lead to future therapies for heart disease in humans.

UC Davis Study Shows that Systemic Inflammation Increases with Age in
Patients at Risk for Heart Disease

UC Davis (06-Oct-11)
the older a study participant was, the higher their blood levels of systemic
inflammation markers. Blood levels of vascular inflammation markers
remained stable across ages. "It could be that we accumulate an inflammatory
load over a lifetime."

Subcategory: Dermatology

How Key Genes Cooperate to Make Healthy Skin
Paul Preuss Berkeley News (20-Sep-11)
Mutations in a single gene, the gene for the protein p63, cause numerous
diseases and malformations of the uppermost layer of skin. P63 acts by
directly regulating another protein, Satb1, which is a “genome organizer.”

Subcategory: Education

Brain Scans Support Findings that IQ Can Rise or Fall Significantly During
Adolescence

Wellcome Trust (20-Oct-11)
It is possible that IQ differences are due to some of the subjects being early or
late developers, but it is equally possible that education had a role in changing
IQ, and this has implications for how schoolchildren are assessed.

Subcategory: Geriatrics

Worm Offspring Inherit Longevity Even without the Genes
Sharon Begley Technology Review (20-Oct-11)
New study shows that acquired characteristics can be passed to offspring
without changes to the genetic code. Occurs through "epigenetics": alterations
not in the coding sequence of DNA but in chemical changes that affect
whether genes are expressed.

How Longevity Is Passed On
Cristina Luiggi The Scientist (19-Oct-11)
For the first time researchers, using the Caenorhabditis elegans worm, have
shown that epigenetic changes that increase lifespan can be inherited across
multiple generations.

Subcategory: Immunology/ Infectious Diseases

Scripps Research Team Discovers Treatable Mechanism Responsible for Often
Deadly Response to Flu

Scripps Research Institute (15-Sep-11)
A severe immune reaction called a “cytokine storm” floods the tiny air sacs of
the lungs with fluid and infection-fighting cells, blocking off airways and
damaging body tissues and organs. Cells that orchestrate cytokine storms may
lead to treatment.

Researchers Engineer New Way to Inhibit Allergic Reactions without Side
Effects

Arnie Phifer University of Notre Dame (06-Oct-11)
Therapy centers on a special molecule the researchers designed, a
heterobivalent ligand (HBL), to out-compete allergens like egg or peanut
proteins. Approach prevents allergic reactions from occurring in the first
place.

Subcategory: Musculoskeletal

Photos of the Day: Mechanical Prosthetic Arm
Product Design and Development (10-Oct-11)
Quadriplegic research subjects test arm. Goal is to create mind-controlled
prosthetics to restore some independence to paralyzed people. Also
www.pddnet.com/news-paralyzed-man-uses-mind_powered-robot-arm-to-to
uch-101011/

Subcategory: Oncology

Pancreatic Cancer 4th Most Deadly, Treatments Few
Marilynn Marchione AARP (07-Oct-11)
Part of what makes pancreatic cancer so deadly is that the pancreas is as vital
as the heart, as it makes digestive enzymes and insulin and other hormones
that enable the body to make energy from food.

Grabbing Cancer by the Short and Curlies
Economist (24-Sep-11)
Seeking the solution to how response to cancer drugs can be restored after
tumors begin resisting treatment, scientists find that short hairpin RNAs may
be an important molecular link.

Cells Are Crawling All Over Our Bodies, but How? Biologists Devise New Way
to Watch How Cells Move

Libby Fairhurst Florida State University (18-Oct-11)
Research on worm sperm cell pull-push crawling motions could eventually aid
in the development of therapies that target cell motility in order to interfere with
or block the metastasis of cancer.

Colon Cancer Connection
Anne Doerr Harvard University Gazette (17-Oct-11)
Strikingly high levels of a bacterium, Fusobacterium, in colorectal cancers may
be a sign that it might contribute to the disease and potentially be a key to
diagnosing, preventing, and treating it.

Attacking Cancer Cells with Nanoparticles
Judy Holmes Syracuse University (24-Oct-11)
By coating gold nanoparticles with DNA coded to attract specific types of
drugs, scientists attach drug molecules and coat the nanoparticle surface to
prevent the immune system from attacking the nanoparticle as a foreign
invader.

How Normal Cells Become Brain Cancers
Jason Bardi University of California San Francisco (28-Sep-11)
The pool of cells from which oligodendroglioma tumors emerge normally
divide “asymmetrically” by splitting into two unequal parts. They transform
into cancer cells when they begin dividing symmetrically. May help to
identify new drugs.

Subcategory: Ophthalmology

Biofunctionalized Silk Nanofibers to Repair the Optic Nerve
Michael Berger Nanowerk (12-Oct-11)
Research goal is to test new biomaterial that will provide a permissive growth
support that is orientated and can ultimately develop as a 3D nerve guide that
can be implanted at a site of a nerve lesion to regenerate a traumatized optic
nerve.

Subcategory: Pain Management

Scientists Discover Inflammation Is Controlled Differently in Brain and Other
Tissues

Scripps Research Institute (20-Oct-11)
Study focuses on the type of inflammation normally treatable with
non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin or
ibuprofen. Shows this type of inflammation is controlled by different
enzymes in different parts of the body.

Subcategory: Pulmonary/ Respiratory Diseases

Breathing Easier with Lung Regeneration
Harvard University Gazette (27-Oct-11)
Stem cells cloned from fthe human airway can form into the lung’s alveoli air
sac tissue.The cells are rapidly deployed in a dynamic process of lung
regeneration to combat damage from infection or chronic disease.

Subcategory: Wound/Tissue Repair

Hold Your Forces: Mechanical Stress Can Help or Hinder Wound Healing
Depending on Time of Application

Abby Robinson Georgia Tech (24-Oct-11)
Applying mechanical forces to an injury site immediately after healing began
disrupts vascular growth into the site, preventing bone healing. Applying
mechanical forces later in the healing process enhanced functional bone
regeneration.

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	RESEARCH TOOLS

Subcategory: Cardiology/ Vascular Diseases

HeartLander Surgical Robot Inches Closer to Reality
Meghan Kerry Design News (06-Oct-11)
A miniature robotic device crawls around the surface of the heart in an
inchworm-like fashion, taking measurements and performing simple surgical
tasks. Gains access to the heart without opening the chest and operates on the
heart while it is beating.

Subcategory: Evolution Research

Discovered: The ‘Missing Link’ in Biological Pigment Biosynthesis
Tracey Duncombe BBSRC (05-Oct-11)
Heme has been found to be made via a novel branch to the well-understood
pathway in a wide range of organisms, from most bacteria to humans.
Involves a related molecule called siroheme, which is hijacked and brought into
the biosynthesis pathway.

Subcategory: Imaging

Microscopy Reveals New Layout For Measles Virus
Carmen Drahl Chemical & Engineering News (31-Oct-11)
The 3-D organization of measles virus appears to be different than what
researchers had expected. A protein-nucleic acid complex found via electron
microscopy studies could help design drugs that combat related viruses, such
as flu.

Subcategory: Materials

New Technique Turns Viruses Into Useful Tools
Prachi Patel Technology Review (20-Oct-11)
In one simple step, viruses can be turned into sophisticated structures with
biomedical properties for growing soft tissue, teeth, and bone. Traits be
genetically modified and many different useful materials can be attached to its
surface.

Subcategory: Mobile Medicine

Report: Future of Health Is Mobile, but Outcomes Count
Neil Versel mobihealthnews (06-Oct-11)
Telemedicine and mobile health may provide more affordable ways to manage
treatment of chronic conditions, offer substantial cost savings from improving
drug adherence and monitoring vital signs, in industrialized, developing areas.

Subcategory: Mouse/ Rat Models

Researchers Engineer Mice with Anomalies Linked to Autism, Schizophrenia
Erica Westly Technology Review (04-Oct-11)
By creating animals with chromosomal abnormalities that mirror those seen in
humans with autism and schizophrenia, researchers hope to learn more about
how the disorders develop.

Subcategory: Oncology

Berkeley Lab Scientists Develop New Tool for the Study of Spatial Patterns in
Living Cells

Lynn Yarris Berkeley News (31-Oct-11)
Biology is a game of nanometers, where spatial differences of only a few
nanometers can determine the fate of a cell – whether it lives or dies, remains
normal or turns cancerous. Gold membranes are used to study cancer
metastasis, T cell immunology.

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Copyright 2011, Technology Management Associates, Inc. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

	

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