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BioTechCircle News®

 

May 2011

 

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Issue 95

See all previous issues at Archives.

 

You can now follow our comments and updates on Twitter: http://twitter.com/BioTechCircle

 

In this articles section: links to 67 free Web articles in 12 major categories.

There are several fewer articles than we’ve been recently summarizing, due to our trip to Japan in mid-May. Our June issue should return to our normal level of 70-80 articles.

 

The major categories are in alphabetical order and further subdivided to make it easy for you to locate news and developments in technology, the business and the markets in the life science areas of interest to you. We’ve provided brief synopses to help you decide which articles you’d like to read. Simply click on the title to go directly to the original article.

 

Here are the major categories.

 

Agri-Biotech (14 articles)

Biobusiness Management (4 articles)

Contract Services (1 article)

Diagnostic Tools (2 articles)

Industry (8 articles)

Novel Applications (5 articles)

Organizations (2 articles)

People Profiles (3 articles)

Platform Technologies (11 articles)

Research Advancements (9 articles)

Research Tools (7 articles)

Strategic Relationships (1 article)

 

For a brief explanation of how we categorize the articles, please see "Express Guide to Monthly Web Articles".

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AGRI-BIOTECH

Subcategory: Animal

Feral Camels Plague Australian Outback

Jessica Marshall DiscoveryNews (17-May-11)

Feral camels in the Australian desert are attacking air conditioning units, toilet

systems and more in a desperate search for water. A new program aims to

track the camels by allowing people to report sightings using Google maps.

Subcategory: Crops

Formidable Fungal Force Counters Biofuel Plant Pathogens

David Gilbert DOE Joint Genome Institute (03-May-11)

Researchers compare genomes of 2 rust fungi to identify the characteristics by

which these pathogens can invade their plant hosts; aim: target factors that

could reduce the growth of plant biomass, develop methods of controlling the

damage they can cause.

ISU Research Leads to Understanding of How Crops Deal with Stress – Yield’s

Biggest Enemy

Iowa State University (25-Apr-11)

When a plant is under stress such as drought, flood or heat, its cells produce

poorly folded or unfolded proteins, setting off an "alarm" that inhibits growth.

This affects yield more than crop pests and diseases. Study to find way to

silence this alarm.

Subcategory: Energy/ Fuel

Spikemoss Genome Offers New Paths for Biofuels Research--Bridges Plant

Development Gap

David Gilbert DOE Joint Genome Institute (05-May-11)

The DNA sequence of a small plant resembling Christmas trees is providing

researchers with information that could influence the development of

candidate biofuel feedstock plants and offering botanists long-awaited insights

into plant evolution.

Discovery Opens the Door to Electricity from Microbes

University of East Anglia (23-May-11)

The exact molecular structure of the proteins which enable bacterial cells to

transfer electrical charge is demonstrated. Leads to developing ways to

‘tether’ bacteria directly to electrodes - creating efficient microbial fuel cells or

‘bio-batteries’.

Subcategory: Environment

Explained: Measuring Earthquakes

Peter Dizikes MIT News (10-May-11)

Earthquakes produce many types of waves, which radiate from its epicenter

and move with a wide variety of frequencies. The moment magnitude measure

relates more to what is going on at the fault itself, helping understand where,

why of earthquakes.

Subcategory: Food

Watching Garlic Slay Bacteria

Erika Gebel Chemical & Engineering News ( 05-May-11)

Garlic and diallyl sulfide show more-potent antibacterial activity at room

temperature than when refrigerated, as the DNA, proteins, and particularly

the membranes of the bacteria become chemically dismantled in their presence.

How To Brew Beer Without Water

Dr. Bernard Talbot IMPO (20-May-11)

In areas where water is scarce and water quality highly suspect, beer quality

is often compromised and production schedule disrupted. The use of properly

treated effluent presents the brewer with a safer option and greater security

of supply.

Food Distributor Using DNA to Track Beef

Michael Felberbaum Manufacturing.net (01-Jun-11)

People want to know where their food is coming from. Being able to follow

cuts of beef back to the ranch can pay off in multiple ways, including boosting

consumer confidence, upping the value of a dinner, cutting the time needed

to track recalled meats.

Subcategory: Materials

Turn Weeds into Cupholders? Dandy Idea

Automotive News (30-May-11)

Scientists plan to transform dandelions into cupholders, floor mats and other

interior trim pieces. The weed produces a milky white substance that

improves the strength of plastics, thus a potential alternative to

petroleum-based synthetic rubber.

Subcategory: Microorganisms

It Takes a Community of Soil Microbes to Protect Plants From Disease

Dan Krotz Berkeley News (05-May-11)

Plants rely on a complex community of soil microbes to defend themselves

against pathogens, much as mammals harbor a raft of microbes to avoid

infections. All of a soil patch's microbes found working together to reduce the

incidence of fungal infection.

Same Fungus, Different Strains: A Comparative Genomics Approach for

Improved “Green” Chemical Production

David Gilbert DOE Joint Genome Institute (13-May-11)

Learning more about the genetic bases of the behaviors and abilities of 2

strains of the industrially relevant fungus Aspergillus niger may lead to more

efficient production of organic acids and other compounds, including biofuels.

Genome of Marine Organism Reveals Hidden Secrets

Mario Aguilera UC San Diego (09-May-11)

First insights provided of the genome of Lyngbya majuscula 3L, a Caribbean

organism that generates compounds that are being developed for potential

treatment against cancer and neurodegenerative diseases.

Tiny Talk on a Barnacle's Back

Scott LaFee UC San Diego (10-May-11)

Using a new form of imaging mass spectrometry, researchers dramatically

visualize multiplex microbial interactions. Helps to better detect, characterize

molecules involved, perhaps discover better therapeutic, commercially

valuable compounds.

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BIOBUSINESS MANAGEMENT

Subcategory: Databases

Can You Identify Your White Space?

Ken Appel Manufacturing.net (01-Jun-11)

With regard to human and animal health, understanding where white space

(gaps in procedures, information and knowledge) exists is critical. Example:

comply with FDA-requested data on continuous monitoring of critical

temperature environments.

Subcategory: Environment

Panasonic Sees Light after Darkness of Disaster

Tomoko A. Hosaka Manufacturing.net (20-May-11)

Japanese electronics company believes it can turn disaster into opportunity as

the country rethinks its energy policy.Its recent move toward

environmentally friendly products and renewable energy technologies now

poised to pay off.

Subcategory: Patent/Intellectual Property Issues

Patent Office Delays Reforms

Glenn Hess Chemical & Engineering News (27-Apr-11)

Because of a shortfall in funding, the U.S. Patent & Trademark Office (PTO)

says it has been forced to put plans for an expedited patent examination

process and the opening of its first regional office on an indefinite hold.

Philip Morris Buys Patent For Smoke-Free Nicotine Device

Michael Felberbaum IMPO (26-May-11)

The world's largest nongovernmental cigarette seller bought the patent for an

aerosol nicotine-delivery system. "Hopefully it's a wave of the future that

inhaling combusted, burning tobacco will someday be a thing of the past,"

says inventor.

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CONTRACT SERVICES

Subcategory: Biomanufacturing

Shock To The System

Rick Mullin Chemical & Engineering News (16-May-11)

FDA admitts that rapid globalization in drug manufacturing outstrips its

resources for inspecting foreign facilities. Risk of unsafe ingredients entering

the supply chain as drugmakers outsource more active pharmaceutical

ingredient (API) production.

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DIAGNOSTIC TOOLS

Subcategory: Immunology/ Infectious Diseases

Low-cost Sensor Can Diagnose Bacterial Infections

Liz Ahlberg University of Illinois (27-Apr-11)

An "artificial nose" is an array of 36 cross-reactive pigment dots that change

color when they sense chemicals in the air. This quick, simple method to

identify infectious bacteria by smell takes hours instead of days, thus

potentially saving lives.

Subcategory: Proteomics

Detecting Misfolded Protein Aggregates

Laura Cassiday Chemical & Engineering News (29-Apr-11)

New assay detects small, soluble aggregates of misfolded proteins that form at

early stages of diseases such as Alzheimer’s, Parkinson’s, and type 2

diabetes. Could enable earlier diagnosis than is now possible.

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INDUSTRY

Subcategory: Biomarker

Biomarker Researchers Seek Qualified Successes

Alan Dove Drug Discovery & Development (01-May-11)

Discusses challenges to biomarker development. Example: a good cancer

biomarker study would test both tumor tissue and normal tissue from each

patient, ideally including patients with different stages of the same type of

tumor.

Subcategory: Disease Prevention

Salmonella Outbreak Linked to Laboratories

Jyllian Kemsley Central Science (10-May-11)

The U.S. Centers for Disease Control & Prevention (CDC) has traced

Salmonella Typhimurium infections to exposure in clinical and teaching

laboratories. CDC reminds lab workers of good microbiology lab practices.

Subcategory: Educational Issues

Full of Sound and Fury

Anna Wells IMPO (31-May-11)

Lists the current 10 most lucrative college majors, 8 of which are engineering

specialties. "Pharmacy and Pharmaceutical Sciences and Administration"

ranks 9th. Cites high dropout rate for such STEM (science, technology,

engineering and math) fields.

Subcategory: Geographic focus

Japan Rebuilds

Jean-François Tremblay Chemical & Engineering News (23-May-11)

Beginning of special report on Japan examining the impact of the March 11

catastrophe on the country’s chemistry research and chemical business

communities and how the disaster is affecting nuclear energy policy in the

U.S. Links.

Subcategory: Miscellaneous News

Five New Hot Spots Where Medicine and Technology Will Converge

Sheryl Weinstein New Jersey Institute of Technology (26-May-11)

Convergence areas: Point of care health care communication; optical imaging

for diagnosing; bioelectronics, bio-nano-sensor technology and neural

engineering; tissue engineering and regenerative medicine; medical or

bio-robots.

Strange Scientific Discoveries So Far this Year

David R. Butcher ThomasNet News (24-May-11)

Butcher presents a month-by-month synopsis of announced innovation and

breakthroughs in science. January: Cause of Baldness Identified. March:

Naps May Boost Your Brainpower. Additional links to "also of note"

articles.

Subcategory: Proteomics

What is Chemical Biology? Perhaps it’s Peptidomimetics

Sidechain Bob Central Science (02-May-11)

Undergrad student explores the inherent problems in using peptides as drugs,

the research goals to overcome those problems and why the peptidomimetics

field belongs in chemical biology category rather than medicinal chemistry.

Improving Peptides

Ann M. Thayer Chemical & Engineering News (30-May-11)

Unlocking fundamental limitations of peptide therapeutics such as poor

stability, short half-life and digestability by protein-eating enzymes in the

body might produce the largest superclass of drugs that the industry has ever

generated.

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NOVEL APPLICATIONS

Subcategory: Energy/ Fuel

Hydrogen Fuel Tech Gets Boost from Low-Cost, Efficient Catalyst

Melinda Lee SLAC National Accelerator (02-May-11)

When dotted with molybdenum sulfide, an inexpensive substitute for

platinum, silicon pillars efficiently generate hydrogen gas from the hydrogen

ions liberated by splitting water when exposed to sunlight.

Subcategory: Environment

Gernot Riether’s Cocoon-Like Sugarcane Buildings Win AIA Competition

Tafline Laylin Inhabitat (28-May-11)

Installed in less than 2 days, award-winning building is fabricated from

material made from glycol-modified polyethylene terephthalate (PETG)

comprised of either recycled plastic or sugar cane locally grown in New

Orleans.

UF Develops Method to Make Plastic from Discarded Plant Material

Robert H. Wells University of Florida (31-May-11)

As we start using more and more bioplastics, we are infringing upon the use of

food material. New method uses a strain of bacteria to create bioplastic from

discarded plant material, such as yard waste.

Subcategory: Environmental

Stunning ‘Virtue of Blue’ Chandelier Made From 500 Fluttering Solar Butterflies

Bridgette Meinhold Inhabitat (24-May-11)

500 butterflies cut from sapphire blue photovoltaic cells flutter around a

hand-blown glass bulb, collecting the sun' energy by day to power the lamp at

night.

Subcategory: Miscellaneous

The Use of Twitter to Track Levels of Disease Activity and Public Concern in the

U.S. During the Influenza A H1N1 Pandemic

Alessio Signorini, Alberto Maria Segre, Philip M. Polgreen PLOSone (04-May-11)

While the costs of tracking disease outbreaks in real-time based on emergency

department data is prohibitive, study establishes a model for using Twitter to monitor

disease activity.

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ORGANIZATIONS

Subcategory: Academia/ Laboratories

Mobile apps for classrooms receive Mira Award for education

Steve Tally Purdue News (12-May-11)

Text messages, Twitter, Facebook and smartphone video camera technologies

are used to enhance the traditional classroom at Purdue. Classroom apps

HotSeat, Mixable and DoubleTake win Mira award for education.

Subcategory: Geographic focus

Vienna Receives “World City Closest to Sustainable Waste Management” Award

Advantageaustria.org (26-Apr-11)

The "World City Closest to Sustainable Waste Management“ award honors

the exceptional efforts the city of Vienna has made in order to strengthen its

position in the environmental and sustainable waste management sector.

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PEOPLE PROFILES

Subcategory: Education

Salman Khan: The Messiah of Math

Bryant Urstadt Business Week (19-May-11)

Free website, dubbed the Khan Academy, may well be the most popular

educational site in the world. About 2 million students visited in April 2011.

Site is supported by grants and donations by Gates Foundation and others.

Subcategory: Food

Sharing Profits with 45,000 Farmers

Karen E. Klein Business Week (17-May-11)

Divine Chocolate is the first chocolate brand to share with its farmers the

profits generated from the beans they grow, harvest, ferment, and dry on

bamboo racks in Ghana, West Africa. The Ghanaian gross national income per

capita was around $700 in 2008.

Subcategory: Psychiatry/ Psychology

Genderless Baby Storm Stocker Ignites a Firestorm with Parents, Media

Jill Fehrenbacher Inhabitots (30-May-11)

A Toronto couple has decided to conceal the sex of their baby, citing it to be a

way to explore gender freedom, and allow their child to develop free from the

potentially harmful pink and blue stereotypes.

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PLATFORM TECHNOLOGIES

Subcategory: Computing Systems

Revolutionary New Paper Computer Shows Flexible Future for Smartphones and

Tablets

Queens University (04-May-11)

A new generation of computers are super lightweight, thin-film and flexible.

They use no power when nobody is interacting with them. When users are

reading, they don’t feel like they’re holding a sheet of glass or metal.

Subcategory: Energy/ Fuel

Combining Gas and Diesel Engines Could Yield Best of Both Worlds

Louise Lerner Argonne National Laboratory (04-May-11)

Researchers seek to combine the efficiency of diesel with the cleanliness of gas

engines New approach results in better efficiency and cleaner emissions, but

sacrifices some of the power density for peak power demand.

U-M Researchers Working toward Efficient Harvesting of Solar Energy

Matt Nixon University of Michigan (03-May-11)

A method for utilizing metal nano-particles with tailored optical properties,

which act much like nanometer-sized light antennae, help accelerate the

production of renewable solar fuels and other chemicals.

Subcategory: Environment

Solar-Thermal Flat Panels that Generate Electric Power

Ed Hayward Boston College (02-May-11)

High-performance nanotech materials arrayed on a flat panel platform

demonstrated 7-8 x higher efficiency than previous solar thermoelectric

generators; opens up solar-thermal electric power conversion to a broad range

of residential and industrial uses.

Silver Cycle: New Evidence for Natural Synthesis of Silver Nanoparticles

Michael Baum NIST (10-May-11)

Useful as antibacterial and antifungal agents, silver nanoparticles increasingly

are being used in a wide variety of products. Some of the nanoparticles of

silver being found increasingly in the environment may be due to processes of

nature.

What Lies Beneath the Seafloor

University of Miami (03-May-11)

Research team studies dynamic microbial life inside Earth's crust to better

understand the natural processes taking place below the seafloor, which also

give rise to economically important ores along the seafloor and may play a

role in earthquakes.

Subcategory: Immunology/ Infectious Diseases

Max Planck Researcher Zaps Deadly Bacteria Using Space Technology

Technology Transfer Tactics (01-Jun-11)

A new way to keep hospital patients safe from infections, especially with the

rise in super-strains of bacteria: plasma, a superheated, electrically charged

gas. Cold plasma for home use could disinfect personal items such as

toothbrushes and razors.

Subcategory: Lab-on-a-chip/ DNA Chips/

New Chip Produces DNA Faster, Less Expensively

Richard Merritt Duke University (27-May-11)

A 1x3" chip that can produce custom-made segments of DNA in 2 days in

what it now takes many large pieces of equipment and significant manpower

to produce in 2 weeks. could have broad implications in the production and

screening of new drugs.

Subcategory: Materials

New Material Could Improve Safety for First Responders to Chemical Hazards

Susan Brown UC San Diego (29-Apr-11)

Carbon nanostructure sensors could warn emergency workers when carbon

filters in the respirators they wear to avoid inhaling toxic fumes have become

dangerously saturated.

Subcategory: Miscellaneous

Mixing Fluids Efficiently in Confined Spaces? Let Viscous Fingers Do the Stirring

Denise Brehm MIT Civil & Environmental (12-May-11)

With 2 fluids of highly contrasting viscosity, the thinner fluid naturally

creates disorder, which proves to be a marvelously efficient means of mixing.

Links to movies showing simulated formation of "fingers," microfluidic

channels.

Subcategory: Proteomics

Unnatural Backbone Mimics a-Helix

Celia Arnaud Chemical & Engineering News (11-May-11)

By adding ß- and ?-amino acids to peptides, researchers show it is possible to

create structural mimics of a-helices that are more stable and potentially more

useful than the natural versions. Could lead to designed peptides with

desirable properties.

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RESEARCH ADVANCEMENTS

Subcategory: Hematology

Team Solves Decades-old Molecular Mystery Linked to Blood Clotting

Diana Yates University of Illinois (31-May-11)

Describes insights developed at an atomic level of how most of the

blood-clotting proteins interact with membranes, an interaction that’s known

to be essential to blood clotting. Among tools: supercomputer simulations,

nanodiscs, solid-state NMR.

Subcategory: Immunology/ Infectious Diseases

Antibiotic Resistant Gene Spreading

Drug Discovery & Development (31-May-11)

An enzyme associated with extensive antibiotic resistance called New Delhi

metallo-ß-lactamase-1 (NDM-1) has been found in 2 people in the Toronto

area. Worldwide travel, medical tourism and its ability to transfer between

bacteria are causes.

Scientists Paint Chemical Picture of Antibiotic-Resistant Bacteria

Squire Booker Penn State (28-Apr-11)

Scientists discover a novel strategy by which antibiotic-resistant bacteria

change their genetic make-up to evade multiple antibiotics. Mechanism for

methylation can lead to compounds that could work in conjunction with

typical antibiotics.

Deadly Bacteria May Mimic Human Proteins to Evolve Antibiotic Resistance

Steve Yozwiak The Translational Genomics Research Institute (TGen) (01-Jun-11)

Using genomic sequencing, study identifies several methyltransferase protein

families that are very similar in otherwise very distantly related human

bacterial pathogens. Could help develop molecular targets in the development

of new drug treatments.

Subcategory: Metabolism: Obesity, Diabetes

Researchers Discover Mechanism That Could Convert Certain Cells into

Insulin-Making Cells

Enrique Rivero UCLA Newsroom (29-Apr-11)

People who don't have enough pancreatic beta cells to produce the insulin

necessary to regulate their blood sugar levels develop diabetes. Scientists may

have discovered underlying mechanism that could convert other cell types into

pancreatic beta cells.

Subcategory: Neurology

FMI Scientists Discover Brain Structures Associated with Learning

Friedrich Miescher Institute (02-May-11)

Neuronal connections are formed in the brain when learning occurs, ensure the

precision of memory. Findng represents an important step toward an

improved understanding of how learning and memories are stored in the brain.

Cancer Drug Holds Promise as First Treatment for Common, Inherited Dementia

Deborah Wormser Southwestern Medical Center (01-Jun-11)

Suberoylanilide hydroxamic acid (SAHA) holds promise as a first-generation

drug for the prevention and treatment of familial frontotemporal dementia

(FTD), a progressive, inherited neurodegenerative disease for which there is

no treatment.

Subcategory: Oncology

Microrockets Take Off

Lauren Wolf Chemical & Engineering News (26-Apr-11)

Tube-shaped microrockets functionalized with antibodies can cruise through

human blood serum. As they zoom along, the rockets capture cancer cells that

express corresponding antigenic surface proteins.

Subcategory: Wound/Tissue Repair

Cotton Candy-like Fibers Repair Wounds That Won’t Heal

R & D Magazine (03-May-11)

A new borate glass nanofiber material appears to react to body fluids much

faster than silicate glasses, simultaneously slows bleeding, fights bacteria and

other sources of infection, stimulates the body's natural healing mechanisms,

resists scarring.

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RESEARCH TOOLS

Subcategory: Environment

Cheaper Antibody-based Biosensor to Detect Marine Pollutants Faster

BioScholar (06-May-11)

New biosensor uses antibody-based technology and can detect, track and

guide the clean up of oil spills in rivers and sea; shows ability to process

water samples in less than 10 minutes and detects pollutants at levels as low

as a few parts per billion.

Subcategory: Environmental

Top 5 Ways to "Greenify" Your Consumption

Mike Chino My Life Scoop (23-May-11)

Can consumerism and global sustainability ever truly be reconciled? Tips:

learn the source of products you buy; understand eco labels; buy less, borrow

more; smart apps help you eat local; scan and learn green credentails with

Goodguide.

Subcategory: Evolution Research

Evolution, Reversed

Anne Trafton MIT News (11-May-11)

The likelihood of a particular evolutionary adaptation reversing itself is

calculated. A tiny percentage of evolutionary adaptations in a drug-resistance

gene can be reversed, but only if the adaptations involve fewer than 4 discrete

genetic mutations.

Subcategory: Gene Sequences

Pacific Biosciences' $600 Million Decoder Ring

Ashlee Vance Business Week (23-Apr-11)

A superpowerful microscope records, in real time, biological processes on a

molecular scale. This gene sequencer is posed to take an entire strand of

human DNA, with its 3 billion bits of information, and map it out in minutes.

Subcategory: Genome Sequence

The Next Generation In Genome Sequencing

Rick Mullin Chemical & Engineering News (09-May-11)

As sequencing technologies have evolved, so have means of collecting,

analyzing, and sharing the data. Drug companies are signing on with contract

research organizations and joining consortia that share informatics

infrastructures.

Subcategory: Imaging

Microscope – Handy, Quick and Flat

Dr. Frank Wippermann Fraunhofer-Gesellschaft (01-May-11)

Ultrathin microscope consists of a multitude of tiny imaging channels, with

lots of tiny lenses arrayed alongside one another. Each channel records a tiny

segment of the object simultaneously. A computer program then generates the

overall picture.

Subcategory: Mouse/ Rat Models

What Is a Laboratory Mouse? Jackson, UNC Researchers Reveal the Details

Joyce Peterson The Jackson Laboratory (29-May-11)

Most of the mice in use today represent only limited genetic diversity, result

of more than 100 years of selective breeding, which could be significantly

expanded with the addition of more wild mouse populations.

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STRATEGIC RELATIONSHIPS

Subcategory: Collaboration

New Project Aims to Fuse Top-Down and Bottom-Up Approaches in Systems

Biology

Lynn A Nystrom Virginia Tech (11-May-11)

Interdisciplinary research will meld the strengths of top-down and bottom-up

approaches into a single framework, thereby allowing efficient and automated

data-driven analysis to augment models that can be simulated.

 

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